Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β
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- 作者：Jae-Sook Songa ; Eun-Kyung Kima ; Yong-Won Choia ; Won Keun Ohb ; Young-Mi Kima ; ymikim12@hanyang.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; acetyl-CoA carboxylase ; AMPK ; AMP-activated protein kinase ; ARE ; antioxidant response element ; CaMKK ; Ca2 ; +/calmodulin-dependent protein kinase kinase ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; DN ; dominant-negative ; ERK ; extracellular signal-regulated kinase ; GCL ; glutamate-cysteine ligase ; GCLC ; catalytic subunit of glutamate-cysteine ligase ; GCLM ; modifier subunit of glutamate-cysteine ligase ; GSH ; glutathione ; GSK-3β ; glycogen synthase kinase-3β ; HA ; hemagglutinin ; H
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：138-149
- 全文大小：1649 K
文摘
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Nectandrin B, a nutmeg lignan protects hepatocytes against oxidative damage.
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Nectandrin B exerts an indirect antioxidative effect via the activation of Nrf2.
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Both ERK and GSK-3β pathways contribute to the activation of Nrf2 and hepatocyte-protection by nectandrin B.
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Nectandrin B can inactivate GSK-3β through the activation of AMPK in HepG2 cells.