LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction
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- 作者：Jueun Leea ; b ; 1 ; Youngae Junga ; 1 ; Ju Yeon Parka ; Sang-Hak Leec ; Do Hyun Ryub ; dhryu@skku.edu" class="auth_mail" title="E-mail the corresponding author ; Geum-Sook Hwanga ; d ; gshwang@kbsi.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：UPLC/Q-TOF MS ; ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry ; CVD ; cardiovascular disease ; CAD ; coronary artery disease ; MI ; myocardial infarction ; AMI ; acute myocardial infarction ; PCA ; principle component analysis ; PLS-DA ; partial least-squares discriminant analysis ; TC ; total cholesterol ; HDL ; high-density lipoprotein cholesterol ; LDL ; low-density lipoprotein cholesterol ; TG ; triglycerides ; hs-CRP ; high-sensitivity C-reactive protein ; QC ; quality control
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：115
- 期：Complete
- 页码：475-486
- 全文大小：2614 K
文摘
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We applied metabolic profiling in serum of patients with myocardial infarction (MI).
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Gender-specific metabolic patterns in serum of patients with MI were identified.
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LC–MS based profiling and various statistical analysis were used in this study.
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Metabolomics can be used to clarify the mechanism underlying MI and gender difference.