p62 Plays a Specific Role in Interferon-纬-Induced Presentation of a Toxoplasma Vacuolar Antigen
详细信息 查看全文
- 作者：Youngae Lee1 ; 3 ; Miwa Sasai1 ; 3 ; Ji Su Ma1 ; 3 ; Naoya Sakaguchi1 ; 3 ; Jun Ohshima1 ; 3 ; Hironori Bando1 ; 3 ; Tatsuya Saitoh2 ; 4 ; 5 ; Shizuo Akira2 ; 4 ; Masahiro Yamamoto1 ; 3 ; myamamoto@biken.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：13
- 期：2
- 页码：223-233
- 全文大小：3400 K
文摘
- •
IFN-纬 induces ubiquitin and p62 recruitment to Toxoplasma gondii-forming vacuoles
- •
Atg3/5/7/16L1 and Irgm1/m3 are essential for the ubiquitination and p62 recruitment
- •
p62 is dispensable for IFN-纬-induced clearance of T. gondii
- •
p62 plays a specific role in vacuolar-antigen-specific CD8+ T cell activation