刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1360-1366
全文大小:1387 K
卷排序:482
文摘
We discovered an activation of STAT3 during the early differentiation stage of mouse 3T3-L1 preadipocytes. Stat3 knockdown using siRNA blocked cell cycle progression of both preadipoctes and early differentiating cells. Accumulation of lipid droplets was inhibited by Stat3 knockdown. STAT3 protein co-localized with HMGA2, which was reported to promote adipogenesis in a previous study.