Blockade of store-operated calcium entry alleviates high glucose-induced neurotoxicity via inhibiting apoptosis in rat neurons
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- 作者：Zhenkuan Xu kuankuancui@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenzhe Xu xuwenzhe2008@126.com" class="auth_mail" title="E-mail the corresponding author ; Yan Song super326@126.com" class="auth_mail" title="E-mail the corresponding author ; Bin Zhang zhangbin747@126.com" class="auth_mail" title="E-mail the corresponding author ; Feng Li feng.li@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuguang Liu ; ns3000@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Store-operated calcium entry ; Stromal interaction molecule ; High glucose ; Neurotoxicity ; Apoptosis
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：63-72
- 全文大小：2466 K
文摘
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Blockade of SOCE alleviated calcium overload and neurotoxicity after high glucose application.
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Blockade of SOCE inhibited mitochondrial apoptosis after high glucose application.
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SOCE might be a promising therapeutic target in diabetic neurotoxicity.