Exploration of Bcl-2 family and caspases-dependent apoptotic signaling pathway in Zearalenone-treated mouse endometrial stromal cells
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- 作者：Jin Hu ; Minglong Xu ; Yujian Dai ; Xiaolin Ding ; Cheng Xiao ; Hongjun Ji ; Yinxue Xu ; xuyinxue@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ZEA ; Cytotoxicity ; Mouse ; Endometrial stromal cells ; Apoptosis ; Signaling pathway
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：553-559
- 全文大小：2229 K
文摘
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Zearalenone treatment could induce obvious apoptosis of mouse ESCs in a dose-dependent manner.
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Zearalenone treatment could activate caspase-9, caspase-3, and regulate Bcl-2 family members to induce apoptosis of mouse ESCs.
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Inhibitors of Z-VAD-FMK and Z-LEHD-FMK prevent ZEA-induced apoptosis of mouse ESCs.