Evaluating glycogen signal contamination in muscle by ¹³C MRS of the liver

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• 作者：Moyoko Tomiyasu ; Takayuki Obata ; Hiroi Nonaka ; Yukio Nishi ; Hiromitsu Nakamoto ; Yukihisa Takayama ; Hiroo Ikehira ; Iwao Kanno
• 关键词：¹³C MRS ; In vivo ; Human liver ; Glycogen synthesis ; Skeletal muscle
• 刊名：Magnetic Resonance Imaging
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：26
• 期：4
• 页码：572-576
• 全文大小：434 K

文摘

To evaluate the contamination of glycogen signal synthesized in skeletal muscle by that in the liver, long-term monitoring of over 7 h of in vivo [1-¹³C] glycogen synthesis/degradation at the right abdomen and left shoulder was achieved using a 3.0-T clinical MR system. ¹³C MR spectra without localization were obtained from five healthy volunteers before and after oral administration of 85 g of d-glucose, including 10 g of 99 % [1-¹³C] glucose. In all volunteers, the relative signal intensities at the abdomen to those at shoulder were about two- to fivefold, and those of time-course changes at the abdomen and shoulder were dissimilar. It is considered that the quantity of muscle-synthesized glycogen signal at the abdomen is less than that at the shoulder because of the lesser muscle volume at the abdomen, and it may be less affected for evaluating glycogen synthesis/degradation in the liver even without localization pulses.