Expression of receptor activator of nuclear factor-魏B ligand is related to sex differences in collagen-induced arthritis

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• 作者：Zheng Ding^a ; ¹ ; Qi Wang^a ; ¹ ; Xiongxiong Pan^b ; Qin Zhu^a ; Hao Lu^a ; Kunpeng Wang^a ; Xuhao Ni^a ; Yunjie Lu^a ; ^{21298533@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Jian Gu^a ; ^{jiangu0304@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：RANKL ; receptor activator of nuclear factor-魏B ligand ; TRAP ; tartrate-resistant acid phosphatase ; RA ; rheumatoid arthritis
• 刊名：International Immunopharmacology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：28
• 期：2
• 页码：892-896
• 全文大小：558 K

文摘

Osteoclasts are responsible for bone destruction in rheumatoid arthritis, and women show greater disease activity and functional disability than men. This study aimed to examine differences in the pathogenesis of collagen-induced arthritis and osteoclastogenesis between female and male mice in vivo and in vitro. Female mice exhibited worse disease progression and increased osteoclastogenesis, as measured by tartrate-resistant acid phosphatase (TRAP) staining than male mice. Significantly higher levels of CD11b⁺ cells were detected in the bone marrow of female mice than that of male mice. Furthermore, the mRNA expression of receptor activator of nuclear factor-魏B ligand was higher in female mice that were immunized with or without collagen II. These findings highlighted sex differences in arthritis morbidity and suggested that female mice are more likely to develop arthritis than male mice. Further studies are needed to investigate the mechanisms of sex differences in collagen-induced arthritis.