Synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage

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• 作者：Tatyana S. Khlebnicova^a ; Yuri A. Piven^a ; Alexander V. Baranovsky^a ; Fedor A. Lakhvich^a ; Svetlana V. Shishkina^b ; Daina Zicāne^c ; Zenta Tetere^c ; Irisa Rāviņa^c ; Viktors Kumpiņ&scaron ; ^c ; Inese Rijkure^c ; Inese Mieriņa^c ; Uldis Peipiņ&scaron ; ^c ; Māris Turks^c ; ^{maris_turks@ktf.rtu.lv}
• 关键词：Triterpenoid-indazolone hybrids ; Betulonic acid ; Betulinic acid ; Indazolone oximes ; X-ray structure
• 刊名：Steroids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：117
• 期：Complete
• 页码：77-89
• 全文大小：879 K
• 卷排序：117

文摘

Novel lupane triterpenoid-indazolone hybrids with oxime linkage are obtained. This is the first report on oxime esters derived from betulonic and betulinic acid at their C(28). X-ray structure of the hybrid molecule is reported. Purification procedure for betulonic acid via its cyclohexylammonium salt is developed.