Assessing glomerular filtration rate (GFR) in elderly Chinese patients with chronic kidney disease (CKD): A comparison of various predictive equations
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- 作者：Liu Xun ; Wang Cheng ; Tang Hua ; Shi Chenggang ; Chen Zhujiang ; Ye Zengchun ; Lou Tanqi
- 关键词：Chronic kidney disease ; Equations for glomerular filtration rate ; Aged patients with CKD ; Serum creatinine
- 刊名：Archives of Gerontology and Geriatrics
- 出版年：2010
- 出版时间：July-August 2010
- 年：2010
- 卷：51
- 期：1
- 页码：13-20
- 全文大小：567 K
文摘
The aim of this study was to evaluate the applicability of formulas based on serum creatinine (SC) levels in elderly Chinese patients with CKD. A total of 103 elderly CKD patients were investigated. The GFR was estimated with Cockcroft–Gault-equation, MDRD1-equation, abbreviated MDRD-equation, Jelliffe-1973-equation, Mawer-equation, Hull-equation, Jelliffe-1971-equation, SC-reciprocal-equation, Gate-equation and Bjornsson-equation. The accuracy of estimated GFR (eGFR) values was compared with the 99mTc-DTPA-GFR (standardized GFR = sGFR) in elderly CKD patients. Bland–Altman analysis demonstrated that Hull-equation, Cockcroft–Gault-equation and Bjornsson-equation were better than the other ones. However, the agreement limits of all the equations exceeded the prior acceptable tolerances defined as 60 ml/min/(1.73 m2). Linear regressions showed that the slopes of Jelliffe-1973-equation, Cockcroft–Gault-equation and Bjornsson-equation were closer to the identical line. The median of difference of MDRD1-equation, abbreviated MDRD-equation and Gate-equation were smaller. Accuracy of Jelliffe-1973-equation, Cockcroft–Gault-equation and Hull-equation were better than those of the other equations. But 30 % accuracy of all the equations were less than 70 % . When compared the bias as well as accuracy of eGFR with sGFR values in different stages of CKD, GFR estimated by MDRD1-equation, Hull-equation, Cockcroft–Gault-equation and Jelliffe-1973-equation showed good results. These results suggested that when SC was checked with enzymatic method, GFR-estimation equations may show great bias in elderly Chinese CKD patients. Further improved formulas are needed to evaluate renal function in elderly Chinese patients with CKD.