ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells

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• 作者：Takahiro Fujimoto ; Keiko Doi ; Midori Koyanagi ; Toshiyuki Tsunoda ; Yasuo Takashima ; Yasuhiro Yoshida ; Takehiko Sasazuki ; Senji Shirasawa
• 关键词：ZFAT ; Zinc-finger protein ; Apoptosis ; Caspase ; MOLT-4
• 刊名：FEBS Letters
• 出版年：2009
• 出版时间：4 February 2009
• 年：2009
• 卷：583
• 期：3
• 页码：568-572
• 全文大小：504 K

文摘

ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4⁺ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.