ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
详细信息 查看全文
- 作者：Keiko Doi ; Takahiro Fujimoto ; Tadashi Okamura ; Masahiro Ogawa ; Yoko Tanaka ; Yasumasa Mototani ; Motohito Goto ; Takeharu Ota ; Hiroshi Matsuzaki ; Masahide Kuroki ; Toshiyuki Tsunoda ; Takehiko Sasazuki ; Senji Shirasawa
- 关键词：T cell homeostasis ; TCR-mediated response ; ZFAT
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2012
- 出版时间：17 August, 2012
- 年：2012
- 卷：425
- 期：1
- 页码：107-112
- 全文大小：853 K
文摘
ZFAT, originally identified as a candidate susceptibility gene for autoimmune thyroid disease, has been reported to be involved in apoptosis, development and primitive hematopoiesis. Zfat is highly expressed in T- and B-cells in the lymphoid tissues, however, its physiological function in the immune system remains totally unknown. Here, we generated the T cell-specific Zfat-deficient mice and demonstrated that Zfat-deficiency leads to a remarkable reduction in the number of the peripheral T cells. Intriguingly, a reduced expression of IL-7R¦Á and the impaired responsiveness to IL-7 for the survival were observed in the Zfat-deficient T cells. Furthermore, a severe defect in proliferation and increased apoptosis in the Zfat-deficient T cells following T cell receptor (TCR) stimulation was observed with a reduced IL-2R¦Á expression as well as a reduced IL-2 production. Thus, our findings reveal that Zfat is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response.