Efficient preparation of high-quality ⁶⁴Cu for routine use

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• 作者：Tomoyuki Ohya ; Kotaro Nagatsu ; ^{nagatsu.kotaro@qst.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Hisashi Suzuki ; Masami Fukada ; Katsuyuki Minegishi ; Masayuki Hanyu ; Toshimitsu Fukumura ; Ming-Rong Zhang
• 关键词：64Cu ; Cation exchange column ; Large scale production ; Metallic contamination ; Quality control ; Remote control
• 刊名：Nuclear Medicine and Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：43
• 期：11
• 页码：685-691
• 全文大小：955 K

文摘

Copper-64 is an attractive radionuclide for positron emission tomography and is emerging as a radiotherapeutic agent. The demand of ⁶⁴Cu with low metallic impurities has increased because of its wide applications when incorporated with antibodies, peptides, and proteins. In this study, we propose a new separation method to produce high-quality ⁶⁴Cu using a cation exchange column, as well as an automated separation system suitable for large-scale production.

Methods

⁶⁴Cu was produced from an electrodeposited ⁶⁴Ni target via the ⁶⁴Ni(p,n)-reaction with a 24 MeV HH+ beam at 10 eμA (electrical microampere) conducted for 1–3 h. The irradiated target was transported to a hot cell and disassembled remotely. ⁶⁴Cu was separated by a solvent mixture of HCl and acetone on a cation-exchange resin, AG50W-X8. The chemical purity of ⁶⁴Cu final product was evaluated using ion-chromatography coupled with a UV detector and inductively coupled plasma mass spectroscopy for quality as well as metallic impurities.

Results

We obtained ⁶⁴Cu in dried form at a yield of 5.2–13 GBq at the end of separation, or 521 ± 12 MBq/eμA h as the final product within 2.5 h of processing time. The metallic impurities were a satisfactory low level in the order of ppb. Major contaminants of Co and Ni were lower than those samples obtained by a widely accepted separation using an anion-exchange resin.

Conclusion

Using a cation-exchange resin and a systematic operation, we successfully reduced the contamination level of the ⁶⁴Cu product. As a straightforward separation method, which shortened the entire processing time, we obtained a satisfactory amount of high-quality ⁶⁴Cu available for routine use.