Pd-catalyzed ¦Á-arylation of thioamides

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• 作者：Hailei Yu ; Xuliang Liu ; Lei Ding ; Qin Yang ; Bin Rong ; Ang Gao ; Baoguo Zhao ; ^{zhaobg2006@shnu.edu.cn} ; Haifeng Yang
• 关键词：¦Á-Arylation ; Palladium ; Thioamide ; Coupling ; Catalysis
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：12 June, 2013
• 年：2013
• 卷：54
• 期：24
• 页码：3060-3062
• 全文大小：1335 K

文摘

Thioamides are unique and versatile synthetic building blocks with S, N, and ¦Á-C three adjacent nucleophile centers, however, they are rarely used as carbon nucleophiles for transition-metal-catalyzed C-C coupling reactions. This Letter describes the first Pd-catalyzed ¦Á-arylation of thioamides and demonstrated the feasibility of the application of thioamides in coupling chemistry. By the coupling process, a variety of ¦Á-arylated thioamides were prepared in moderate to good yields under mild reaction conditions, which provides an alternative way to access functionalized thioamides as well as a new synthetic transformation for thioamides. High chemoselectivity for thioamide over amide was observed in the reaction.