Clinical implications of hepatitis B surface antigen quantitation in the natural history of chronic hepatitis B virus infection

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• 作者：Zhaoxia Tan^a ; ^c ; Maoshi Li^a ; ^c ; ¹ ; Xuemei Kuang^a ; ^c ; Yu Tang^a ; ^c ; Yi Fan^a ; ^c ; Guohong Deng^a ; ^c ; Yuming Wang^a ; ^c ; Dengming He^a ; ^b ; ^c ; ^{hedengming@gmail.com" class="auth_mail}
• 关键词：HBsAg quantitation ; HBV DNA ; Age ; Natural history
• 刊名：Journal of Clinical Virology
• 出版年：April, 2014
• 年：2014
• 卷：59
• 期：4
• 页码：228-234
• 全文大小：1668 K

文摘

Background

HBsAg quantitation may be useful for managing patients with hepatitis B virus (HBV) infection.

Objectives

We explored the clinical implications of HBsAg quantitation for patients with HBsAg levels >250 IU/ml (Abbott Diagnostics).

Study design

Two hundred and thirty-three HBV-infected patients comprising 29 immune tolerance cases, 49 treatment-na茂ve HBeAg-positive chronic hepatitis B (CHB) cases, 91 inactive HBV carrier cases, and 64 treatment-na茂ve HBeAg-negative CHB cases were analyzed. HBsAg was quantified by the Architect HBsAg assay (Abbott Diagnostics) after a 1:500 automated dilution.

Results and conclusions

HBsAg (log 10 IU/ml) was established for immune tolerance (4.50 卤 0.43), HBeAg-positive CHB (4.17 卤 0.66), inactive HBV carrier (3.32 卤 0.44), and HBeAg-negative CHB (3.23 卤 0.40); (p = 4.92 脳 10^鈭?5). No significant difference was observed between inactive HBV carrier and HBeAg-negative CHB (p = 0.247). The proportions of HBsAg <2000 IU/ml for inactive HBV carrier and HBeAg-negative CHB were 51.6% and 59.3%, respectively (p = 0.341). Positive correlations between HBsAg and HBV DNA were observed for immune tolerance (p = 1.23 脳 10^鈭?) and HBeAg-positive CHB (p = 0.003), but not for HBeAg-negative CHB (p = 0.432). A negative correlation between HBsAg and age was observed for immune tolerance (p = 0.030), HBeAg-positive CHB (p = 0.016), and inactive HBV carrier (p = 0.001), but not in HBeAg-negative CHB (p = 0.249). No significant differences between HBsAg and ALT for HBeAg-positive (p = 0.338) or HBeAg-negative CHB (p = 0.564) were observed. For patients with HBsAg quantitation >250 IU/ml, HBsAg may reflect HBV DNA replication for HBeAg-positive cases. HBsAg is not a suitable marker for evaluating hepatitis activity and distinguishing between cases of HBeAg-negative CHB and inactive HBV carrier state.