LRP5 and LRP6 in development and disease

详细信息    查看全文

• 作者：Danese M. Joiner¹ ; Jiyuan Ke² ; Zhendong Zhong¹ ; H. Eric Xu² ; Bart O. Williams¹ ; ^{Bart.Williams@vai.org}
• 关键词：LRP5/6 ; Wnt/¦Â-catenin ; development ; crystal structure ; disease
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：24
• 期：1
• 页码：31-39
• 全文大小：1110 K

文摘

Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions including osteoporosis, cancer, and metabolic disease. Here, we discuss the links between alterations in LRP5/6 and disease, proteins that interact with them, and insights gained into their function from mouse models. We also highlight current drug development related to LRP5/6 as well as how the recent elucidation of their crystal structures may allow further refinement of our ability to target them for therapeutic benefit.