Green tea epigallocatechin-3-gallate alleviates Porphyromonas gingivalis-induced periodontitis in mice
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- 作者：Yu Caia ; ZhiBin Chena ; Hao Liub ; Yan Xuana ; XiaoXuan Wanga ; QingXian Luana ; kqluanqx@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epigallocatechin-3-gallate (EGCG) ; Porphyromonas gingivalis (P. gingivalis) ; Periodontitis ; Cytokine ; Bone resorption
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：839-845
- 全文大小：854 K
文摘
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We established a mouse model of periodontitis by oral infection with P. gingivalis.
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We used epigallocatechin-3-gallate (EGCG) to down-regulate inflammatory mediators.
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Serum, gingival tissue and bone were examined to assess the effect of EGCG.
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Oral continuous intake of EGCG alleviates P. gingivalis-induced periodontitis.
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EGCG treatment could provide a potential therapeutic to prevent periodontal disease.