Constructing a novel 8-hydroxy-2′-deoxyguanosine electrochemical sensor and application in evaluating the oxidative damages of DNA and guanine
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- 作者：Zhipan Guo ; Xiuhui Liu ; liuxh@nwnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuelin Liu ; Guofan Wu ; Xiaoquan Lu ; luxq@nwnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：8-Hydroxy-2&prime ; -deoxyguanosine ; Carbon nanotubes ; Oxidative DNA damage ; Guanine base ; Oxidation assessment
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：671-676
- 全文大小：1102 K
文摘
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A novel 8-OHdG sensor based on MWCNTs/GCE was fabricated.
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The sensor exhibited a super-low detection limit toward the 8-OHdG(18.8 nM).
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The sensor can detect the 8-OHdG generated from the damaged DNA and guanine.
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The work established an association between 8-OHdG and degree of DNA damage.