PPARγ inhibits HMGB1 expression through upregulation of miR-142-3p in vitro and in vivo
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- 作者：Zhiqiang Yuan ; yzqcqburn@163.com" class="auth_mail" title="E-mail the corresponding author ; Gaoxing Luo ; Xiaolu Li ; Jing Chen ; Jun Wu ; Yizhi Peng ; yizhipen@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PPARγ ; miR-142-3p ; HMGB1 ; Inflammation
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：28
- 期：3
- 页码：158-164
- 全文大小：783 K
文摘
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PPARγ is inversely correlated with HMGB1.
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PPARγ inhibits the basal and LPS-induced expression of HMGB1 is associated with the upregulation of miR-142-3p.
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PPARγ-induced miR-142-3p is involved in the suppression of LPS-induced inflammatory response in vivo.