Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy
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- 作者：Bjö ; rn Kruspiga ; 1 ; Kadri Valtera ; Belma Skendera ; c ; d ; Boris Zhivotovskya ; b ; Vladimir Gogvadzea ; b ; Vladimir.Gogvadze@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：TTFA ; thenoyltrifluoroacetone ; ROS ; reactive oxygen species ; PARP ; poly (ADP-ribose) polymerase ; OMM ; outer mitochondrial membrane ; NAC ; N-acetylcysteine ; SQR ; succinate ; ubiquinone oxidoreductase ; SDH ; succinate dehydrogenase ; α-TOS ; alpha-tocopheryl-succinate
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1863
- 期：8
- 页码：2065-2071
- 全文大小：1441 K
文摘
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Mitochondria play a pivotal role in apoptosis induction.
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Targeting succinate:ubiquinone reductase sensitizes tumor cells to treatment.
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Chemopotentiating effect of inhibition is mediated by reactive oxygen species.
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Cells with low capacity to oxidize succinate are resistance to sensitization.