Reactive oxygen species regulate a balance between mitotic catastrophe and apoptosis

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• 作者：Irina V. Sorokina^a ; Tatiana V. Denisenko^a ; Gabriela Imreh^b ; Vladimir Gogvadze^a ; ^b ; Boris Zhivotovsky^a ; ^b ; ^{Boris.Zhivotovsky@ki.se}
• 关键词：MC ; mitotic catastrophe ; ROS ; reactive oxygen species
• 刊名：The International Journal of Biochemistry & Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：81
• 期：part_PA
• 页码：133-136
• 全文大小：828 K
• 卷排序：81

文摘

Mitotic catastrophe (MC) is a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses. There are several observations permitting to define MC as an oncosuppressive mechanism. MC can end up in apoptosis, necrosis or senescence. Here we show that the anticancer drug doxorubicin triggers DNA damage and MC independently of ROS production. In contrast, doxorubicin-induced apoptosis was found to be ROS-dependent. Antioxidants NAC or Trolox suppressed apoptosis, but facilitated MC development. Our data demonstrate that evasion of apoptosis and subsequent stimulation of MC can contribute to tumor cell elimination improving anticancer therapy.