Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

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• 作者：Xiufeng Pang ; Jingjing Zhao ; Wen Zhang ; Xiuyuan Zhuang ; Jiesi Wang ; Ruiqi Xu ; Ziliang Xu ; Weijing Qu
• 关键词：Hippophae rhamnoides ; Flavones ; Hypertension ; Hyperinsulinemia ; Angiotensin ||
• 刊名：Journal of Ethnopharmacology
• 出版年：2008
• 出版时间：8 May 2008
• 年：2008
• 卷：117
• 期：2
• 页码：325-331
• 全文大小：327 K

文摘

The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. (TFH-SR) and its underlying mechanism in chronic sucrose-fed rats by evaluating its ability to regulate insulin and angiotensin levels. Feeding of high-sucrose diet (HS: 77 % of kcal from carbohydrate, 16 % from protein and 6 % from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (SBP) by 25.60 % , plasma insulin by 114.24 % , triglycerides by 85.14 % and activated angiotensin contents in heart and kidney. However, TFH-SR treatment significantly suppressed the elevated hypertension, hyperinsulinemia and dyslipidemia. Furthermore, TFH-SR (especially at the dose of 150 mg/kg/day) increased the circulatory blood angiotensin level as effective as angiotensin receptor blocker. These results indicated that TFH-SR exerted its antihypertensive effects at least in part by improving insulin sensitivity and blocking angiotensin signal pathway. Findings of the present study suggested that TFH-SR might prove to be of potential use in the management of hyperinsulinemia in non-diabetic state with cardiovascular diseases.