Versatile Synthetic Method for Sphingolipids and Functionalized Sphingosine Derivatives via Olefin Cross Metathesis

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• 作者：Tetsuya Yamamoto ; Hiroko Hasegawa ; Toshikazu Hakogi ; Shigeo Katsumura
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：November 23, 2006
• 年：2006
• 卷：8
• 期：24
• 页码：5569 - 5572
• 全文大小：153K
• 年卷期：v.8,no.24(November 23, 2006)
• ISSN：1523-7052

文摘

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A highly efficient and versatile method for the synthesis of various sphingolipids, such as sphingomyelin, ceramide, sphingosine, sphingosine1-phosphate, and functionalized sphingosine derivatives, was established by two types of combinations of the olefin cross metathesis reaction.One reaction was between the same olefin part and appropriate amino alcohols, which were prepared starting from N-Boc-L-serine, and theother was between appropriate olefins and the same amino alcohol.