Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-Type Reaction of Oxazolones and Enol Ethers

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• 作者：Robert A. Mosey ; Jason S. Fisk ; Timothy L. Friebe ; Jetze J. Tepe
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 6, 2008
• 年：2008
• 卷：10
• 期：5
• 页码：825 - 828
• 全文大小：122K
• 年卷期：v.10,no.5(March 6, 2008)
• ISSN：1523-7052

文摘

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tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describeherein the synthesis of these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH₄ reduction of theintermediate oxazolone.