Enantioselective Total Synthesis of Peloruside A: A Potent Microtubule Stabilizer

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• 作者：Arun K. Ghosh ; Xiaoming Xu ; Jae-Hun Kim ; Chun-Xiao Xu
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 6, 2008
• 年：2008
• 卷：10
• 期：5
• 页码：1001 - 1004
• 全文大小：82K
• 年卷期：v.10,no.5(March 6, 2008)
• ISSN：1523-7052

文摘

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An enantioselective total synthesis of (+)-peloruside A (1) is described. Peloruside A (1) is a potent microtubule stabilizer with significantclinical potential. The synthesis is convergent and involves the assembly of C1-C10 segment 2 and C11-C24 segment 3 by a novel aldolprotocol followed by Yamaguchi macrolactonization of the resulting seco-acid, selective methylation of hemi-ketal and removal of the protectinggroups to peloruside A.