Chemoenzymatic Dynamic Kinetic Resolution of Allylic Alcohols: A Highly Enantioselective Route to Acyloin Acetates

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• 作者：Krisztiá ; n Bogá ; r ; Pilar Hoyos Vidal ; André ; s R. Alcá ; ntara Leó ; n ; Jan-E. Bä ; ckvall
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 16, 2007
• 年：2007
• 卷：9
• 期：17
• 页码：3401 - 3404
• 全文大小：83K
• 年卷期：v.9,no.17(August 16, 2007)
• ISSN：1523-7052

文摘

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Dynamic kinetic resolution (DKR) of a series of sterically hindered allylic alcohols has been conducted with Candida antarctica lipase B(CALB) and ruthenium catalyst 1. The optically pure allylic acetates obtained were subjected to oxidative cleavage to give the correspondingacylated acyloins in high yields without loss of chiral information.