Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe
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- 作者：Willem J. M. Mulder ; Rolf Koole ; Ricardo J. Brandwijk ; Gert Storm ; Patrick T. K. Chin ; Gustav J. Strijkers ; Celso de Mello Donegá ; Klaas Nicolay ; and Arjan W. Griffioen
- 刊名：Nano Letters
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：6
- 期：1
- 页码：1 - 6
- 全文大小：666K
- 年卷期：v.6,no.1(January 2006)
- ISSN：1530-6992
文摘
MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids,which resulted in a relaxivity, r1, of nearly 2000 mM-1s-1 per quantum dot. The quantum dots were functionalized by covalently linking
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3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the highrelaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.
v3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the highrelaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.