Zinc Chloride-Promoted Aryl Bromide−Alkyne Cross-Coupling Reactions at Room Temperature

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• 作者：Aaron D. Finke ; Eric C. Elleby ; Michael J. Boyd ; Haim Weissman ; Jeffrey S. Moore
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：November 20, 2009
• 年：2009
• 卷：74
• 期：22
• 页码：8897-8900
• 全文大小：692K
• 年卷期：v.74,no.22(November 20, 2009)
• ISSN：1520-6904

文摘

Substoichiometric amounts of ZnCl₂ promote the room temperature, Pd/P(t-Bu)₃-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.