Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes

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• 作者：Yeshua Sempere MolinaJonathan Ruchti ; Erick M. Carreira
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：743-745
• 全文大小：322K
• ISSN：1523-7052

文摘

Enantioselective addition of terminal alkynes to α,α-dichlorinated aldehydes employing Zn(OTf)₂/NME is disclosed. The propargylic alcohols obtained are accessed in good yields and high enantioselectivity from easily accessible α,α-dichloroaldehydes. The method opens new strategic opportunities for the synthesis of chlorinated natural products, such as the chlorosulfolipids.