Duboscic Acid: A Potent α-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from Duboscia macrocarpa
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- 作者：Pascal Wafo ; Ramsay S. T. Kamdem ; Zulfiqar Ali ; Shazia Anjum ; Shamsun Nahar Khan ; Afshan Begum ; Karsten Krohn ; Berhanu M. Abegaz ; Bonaventure T. Ngadjui ; Muhammad Iqbal Choudhary
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：December 17, 2010
- 年：2010
- 卷：12
- 期：24
- 页码：5760-5763
- 全文大小：203K
- 年卷期：v.12,no.24(December 17, 2010)
- ISSN：1523-7052
文摘
Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name “dubosane” is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.