True Chemical Shift Correlation Maps: A TOCSY Experiment with Pure Shifts in Both Dimensions

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• 作者：Gareth A. Morris ; Juan A. Aguilar ; Robert Evans ; Stephan Haiber ; Mathias Nilsson
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：September 22, 2010
• 年：2010
• 卷：132
• 期：37
• 页码：12770-12772
• 全文大小：159K
• 年卷期：v.132,no.37(September 22, 2010)
• ISSN：1520-5126

文摘

Signal resolution in ¹H NMR is limited primarily by multiplet structure. Recent advances in pure shift NMR, in which the effects of homonuclear couplings are suppressed, have allowed this limitation to be circumvented in 1D NMR, gaining almost an order of magnitude in spectral resolution. Here for the first time an experiment is demonstrated that suppresses multiplet structure in both domains of a homonuclear two-dimensional spectrum. The principle is demonstrated for the TOCSY experiment, generating a chemical shift correlation map in which a single peak is seen for each coupled relationship, but the principle is general and readily extensible to other homonuclear correlation experiments. Such spectra greatly simplify manual spectral analysis and should be well-suited to automated methods for structure elucidation.