A Low Cytotoxic Cationic Metal鈥揙rganic Framework Carrier for Controllable Drug Release

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• 作者：Quan Hu ; Jiancan Yu ; Min Liu ; Aiping Liu ; Zhongshang Dou ; Yu Yang
• 刊名：Journal of Medicinal Chemistry
• 出版年：2014
• 出版时间：July 10, 2014
• 年：2014
• 卷：57
• 期：13
• 页码：5679-5685
• 全文大小：415K
• ISSN：1520-4804

文摘

A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal鈥搊rganic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of the neutral crystal MOF-74-Fe(II). This cationic host material exhibits very low cytotoxicity upon PC12 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and high drug loading capacity of ibuprofen anions (15.9 wt %) through ion exchange and salt penetration procedures. Controlled by anion exchange, two mechanisms were involved in the drug release process with different drug delivery rates due to the presence of coordinated or free ibuprofen anions, making the administration of drug release more flexible.