Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition toward Vinyl鈥揋old Intermediate over Alkene

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• 作者：Haihui Peng ; Novruz G. Akhmedov ; Yu-Feng Liang ; Ning Jiao ; Xiaodong Shi
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 22, 2015
• 年：2015
• 卷：137
• 期：28
• 页码：8912-8915
• 全文大小：479K
• ISSN：1520-5126

文摘

A dual catalytic approach enlisting gold and iron synergy is described. This method offers readily access to substituted heterocycle aldehydes via oxygen radical addition to vinyl鈥揼old intermediates under Fe catalyst assistance. This system shows good functional group compatibility for the generation of substituted oxazole, indole, and benzofuran aldehydes. Mechanistic evidence greatly supports selective radical addition to an activated vinyl鈥揂u double bond over alkene. This unique discovery offers a new avenue with great potential to further extend the synthetic power and versatility of gold catalysis.