Regioselective Copper-Catalyzed Boracarboxylation of Vinyl Arenes
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- 作者：Trevor W. Butcher ; Edward J. McClain ; Tyler G. Hamilton ; Trina M. Perrone ; Kayla M. Kroner ; Gregory C. Donohoe ; Novruz G. Akhmedov ; Jeffrey L. Petersen ; Brian V. Popp
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：December 16, 2016
- 年：2016
- 卷：18
- 期：24
- 页码：6428-6431
- 全文大小：438K
- ISSN：1523-7052
文摘
Regioselective copper-catalyzed boracarboxylation of vinyl arenes with bis(pinacolato)diboron and carbon dioxide has been achieved. New boron-functionalized α-aryl carboxylic acids, including nonsteroidal anti-inflammatory drugs (NSAIDs), are obtained in moderate to excellent yields. The synthetic utility of the transformation was shown through subsequent derivatization of the carbon–boron bond yielding formal hydroxy- and fluorocarboxylation products as well as anionic difluoroboralactones.