Bioactive Polyketides from Peperomia duclouxii
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- 作者：Na Li ; Jian-lin Wu ; Toshiaki Hasegawa ; Jun-ichi Sakai ; Li-ming Bai ; Li-yan Wang ; Saori Kakuta ; Yumiko Furuya ; Hirotsugu Ogura ; Takao Kataoka ; Akihiro Tomida ; Takashi Tsuruo ; Masayoshi Ando
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：998 - 1001
- 全文大小：57K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii.The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1),4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A andoleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 valuesthat ranged from 4.4 to 9.6 
g/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calceinaccumulation than verapamil at 2.5 and 25 g/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderateto weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1
or TNF-.
g/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calceinaccumulation than verapamil at 2.5 and 25 g/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderateto weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1or TNF-.