Relationship between the Electron Density of the Heme Fe Atom and the Vibrational Frequencies of the Fe-Bound Carbon Monoxide in Myoglobin

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• 作者：Ryu Nishimura ; Tomokazu Shibata ; Hulin Tai ; Izumi Ishigami ; Takashi Ogura ; Satoshi Nagao ; Takashi Matsuo ; Shun Hirota ; Kiyohiro Imai ; Saburo Neya ; Akihiro Suzuki ; Yasuhiko Yamamoto
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：March 18, 2013
• 年：2013
• 卷：52
• 期：6
• 页码：3349-3355
• 全文大小：295K
• 年卷期：v.52,no.6(March 18, 2013)
• ISSN：1520-510X

文摘

We analyzed the vibrational frequencies of the Fe-bound carbon monoxide (CO) of myoglobin reconstituted with a series of chemically modified heme cofactors possessing a heme Fe atom with a variety of electron densities. The study revealed that the stretching frequency of Fe-bound CO (谓_CO) increases with decreasing electron density of the heme Fe atom (蟻_Fe). This finding demonstrated that the 谓_CO value can be used as a sensitive measure of the 蟻_Fe value and that the 蟺 back-donation of the heme Fe atom to CO is affected by the heme 蟺-system perturbation induced through peripheral side chain modifications.