Biomimetic Synthesis of Lysozyme-Silica Hybrid Hollow Particles Using Sonochemical Treatment: Influence of pH and Lysozyme Concentration on Morphology

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• 作者：Toru Shiomi ; Tatsuo Tsunoda ; Akiko Kawai ; Fujio Mizukami ; Kengo Sakaguchi
• 刊名：Chemistry of Materials
• 出版年：2007
• 出版时间：September 4, 2007
• 年：2007
• 卷：19
• 期：18
• 页码：4486 - 4493
• 全文大小：569K
• 年卷期：v.19,no.18(September 4, 2007)
• ISSN：1520-5002

文摘

The silica precipitation activity of lysozyme and the possibility of controlling the resulting particlemorphologies were investigated. Lysozyme can act as not only a silica precipitation agent but also as acomponent of the precipitation products, namely, forming a composite of lysozyme and silica. Stirringproduced lysozyme-silica hybrid granular particles (L-SHGs), while a sonochemical treatment resultedin lysozyme-silica hybrid hollow particles (L-SHHs). The silica precipitation activity of lysozyme andthe formation of L-SHHs occur only around pH 9. At the optimized pH, the lysozyme concentration wasfound to affect the morphologies of the L-SHHs. Compared with other basic proteins, the foamingproperties of lysozyme appear to be a key factor in the formation of hollow structures. The proposedformation mechanisms of L-SHGs and L-SHHs are also discussed.