Chiral Lewis Base-Assisted Br酶nsted Acid (LBBA)-Catalyzed Enantioselective Cyclization of 2-Geranylphenols
详细信息 查看全文
- 作者：Akira Sakakura ; Masayuki Sakuma ; Kazuaki Ishihara
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：June 17, 2011
- 年：2011
- 卷：13
- 期：12
- 页码：3130-3133
- 全文大小：745K
- 年卷期：v.13,no.12(June 17, 2011)
- ISSN：1523-7052
文摘
Chiral Lewis base-assisted Br酶nsted acids (Chiral LBBAs) have been designed as new organocatalysts for biomimetic enantioselective cyclization. A salt of a chiral phosphonous acid diester with FSO3H catalyzes the enantioselective cyclization of 2-geranylphenols to give the desired trans-fused cyclized products with high diastereo- and enantioselectivities (up to 98:2 dr and 93% ee).