Primary Alkylboronic Acids as Highly Active Catalysts for the Dehydrative Amide Condensation of 伪-Hydroxycarboxylic Acids

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• 作者：Risa Yamashita ; Akira Sakakura ; Kazuaki Ishihara
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3654-3657
• 全文大小：281K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of 伪-hydroxycarboxylic acids. The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.