Antimicrobial Phenolics and Unusual Glycerides from Helichrysum italicum subsp. microphyllum
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- 作者：Orazio Taglialatela-Scafati ; Federica Pollastro ; Giuseppina Chianese ; Alberto Minassi ; Simon Gibbons ; Warunya Arunotayanun ; Blessing Mabebie ; Mauro Ballero ; Giovanni Appendino
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：March 22, 2013
- 年：2013
- 卷：76
- 期：3
- 页码：346-353
- 全文大小：340K
- 年卷期：v.76,no.3(March 22, 2013)
- ISSN：1520-6025
文摘
During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a鈥?b>c, 6鈥?b>8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.