Jahnellamides, 伪-Keto-尾-Methionine-Containing Peptides from the Terrestrial Myxobacterium Jahnella sp.: Structure and Biosynthesis

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• 作者：Alberto Plaza ; Konrad Viehrig ; Ronald Garcia ; Rolf M眉ller
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：15
• 期：22
• 页码：5882-5885
• 全文大小：218K
• 年卷期：v.15,no.22(November 15, 2013)
• ISSN：1523-7052

文摘

Two new cyclic peptides, termed jahnellamides A and B, were isolated from the myxobacterium Jahnella sp. Their structures were solved by NMR, ESIMS, and chemical derivatizations. Jahnellamides are a new class of 伪-ketoamide-containing peptides comprised of nonproteinogenic amino acids, including 伪-keto-尾-methionine and 4-hydroxyglutamic acid. Moreover, in silico analysis of the genome sequence along with feeding experiments allowed us to identify and annotate a candidate nonribosomal peptide synthetase biosynthetic gene cluster containing a polyketide synthase module involved in the formation of the 伪-ketoamide moiety.