Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp. UIC 10339

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• 作者：Shangwen Luo ; Aleksej Krunic ; Hahk-Soo Kang ; Wei-Lun Chen ; John L. Woodard ; James R. Fuchs ; Steven M. Swanson ; Jimmy Orjala
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1871-1880
• 全文大小：343K
• ISSN：1520-6025

文摘

Two new cyclic lipopeptides, trichormamides A (1) and B (2), were isolated from the cultured freshwater cyanobacterium Trichormus sp. UIC 10339. The strain was obtained from a sample collected in Raven Lake in Northern Wisconsin. The planar structures of trichormamides A (1) and B (2) were determined using a combination of spectroscopic analyses including HRESIMS and 1D and 2D NMR experiments. The absolute configurations of the amino acid residues were assigned by the advanced Marfey鈥檚 method after acid hydrolysis. Trichormamide A (1) is a cyclic undecapeptide containing two d-amino acid residues (d-Tyr and d-Leu) and one 尾-amino acid residue (尾-aminodecanoic acid). Trichormamide B (2) is a cyclic dodecapeptide characterized by the presence of four nonstandard 伪-amino acid residues (homoserine, N-methylisoleucine, and two 3-hydroxyleucines) and one 尾-amino acid residue (尾-aminodecanoic acid). Trichormamide B (2) was cytotoxic against MDA-MB-435 and HT-29 cancer cell lines with IC₅₀ values of 0.8 and 1.5 渭M, respectively.