Asymmetric, Catalytic Synthesis of -Chiral Amines Using a Novel Bis(phosphine) Monoxide Chiral Ligand
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- 作者：Alessandro A. Boezio ; Julien Pytkowicz ; Alexandre Cô ; té ; and André ; B. Charette
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：November 26, 2003
- 年：2003
- 卷：125
- 期：47
- 页码：14260 - 14261
- 全文大小：78K
- 年卷期：v.125,no.47(November 26, 2003)
- ISSN：1520-5126
文摘
We have shown that Me-DuPHOS monoxide (BozPHOS) is a very effective ligand in the copper-catalyzed addition of dialkylzinc to N-phosphinoylimines providing access to 
-chiral amines. The new ligand is particularly effective for the addition of the lesser reactive dimethylzinc. The major advantages of this process are high yields, broad substrate scope, and high enantioselectivities with low catalyst loading (3 mol %).
-chiral amines. The new ligand is particularly effective for the addition of the lesser reactive dimethylzinc. The major advantages of this process are high yields, broad substrate scope, and high enantioselectivities with low catalyst loading (3 mol %).