Catalytic Enantioselective Addition of Dialkylzinc to N-Diphenylphosphinoylimines. A Practical Synthesis of -Chiral Amines

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• 作者：Alessandro A. Boezio and André ; B. Charette
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：February 19, 2003
• 年：2003
• 卷：125
• 期：7
• 页码：1692 - 1693
• 全文大小：57K
• 年卷期：v.125,no.7(February 19, 2003)
• ISSN：1520-5126

文摘

The enantioselective addition of dialkylzinc reagents to N-diphenylphosphinoylimines derived from aryl-, furyl-, and cyclopropylaldehydes is efficiently catalyzed by a copper(II) triflate/(R,R)-MeDUPHOS complex. The yields are high (51-98%), and the enantiomeric excesses vary from 85 to 96%. This route provides a practical route to -chiral amines.