Interaction of Tricationic Corroles with Single/Double Helix of Homopolymeric Nucleic Acids and DNA

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• 作者：Alessandro D鈥橴rso ; Sara Nardis ; Giuseppe Pomarico ; Maria Elena Fragal脿 ; Roberto Paolesse ; Roberto Purrello
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：June 12, 2013
• 年：2013
• 卷：135
• 期：23
• 页码：8632-8638
• 全文大小：399K
• 年卷期：v.135,no.23(June 12, 2013)
• ISSN：1520-5126

文摘

In this manuscript a multitechnique approach is proposed to characterize the interaction between new tri-N-methylpyridyl corrole (TMPC) and its germanium(IV) derivative (GeTMPC), with single- and double-stranded nucleic acid homopolymers and calf thymus DNA. The specificity of each spectroscopic technique has been exploited to analyze the different aspects of corrole binding. Noteworthy, this approach allows us to distinguish between H aggregation of TMPC in the presence of polyriboadenilic acid (poly(rA)) and J aggregates in the presence of polyribocytidinic acid (poly(rC)) as well as to identify the formation of GeTMPC dimers in the presence of single-stranded poly(rA) and pseudointercalation with single-stranded poly(rC).