Multilayered Magnetic Gelatin Membrane Scaffolds
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- 作者：Sangram K. Samal ; Vitaly Goranov ; Mamoni Dash ; Alessandro Russo ; Tatiana Shelyakova ; Patrizio Graziosi ; Lisa Lungaro ; Alberto Riminucci ; Marc Uhlarz ; Manuel Ba帽obre-L贸pez ; Jose Rivas ; Thomas Herrmannsd枚rfer ; Jayakumar Rajadas ; Stefaan De Smedt ; Kevin Braeckmans ; David L. Kaplan ; V. Alek Dediu
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2015
- 出版时间：October 21, 2015
- 年：2015
- 卷：7
- 期：41
- 页码：23098-23109
- 全文大小：712K
- ISSN：1944-8252
文摘
A versatile approach for the design and fabrication of multilayer magnetic scaffolds with tunable magnetic gradients is described. Multilayer magnetic gelatin membrane scaffolds with intrinsic magnetic gradients were designed to encapsulate magnetized bioagents under an externally applied magnetic field for use in magnetic-field-assisted tissue engineering. The temperature of the individual membranes increased up to 43.7 掳C under an applied oscillating magnetic field for 70 s by magnetic hyperthermia, enabling the possibility of inducing a thermal gradient inside the final 3D multilayer magnetic scaffolds. On the basis of finite element method simulations, magnetic gelatin membranes with different concentrations of magnetic nanoparticles were assembled into 3D multilayered scaffolds. A magnetic-gradient-controlled distribution of magnetically labeled stem cells was demonstrated in vitro. This magnetic biomaterial鈥搈agnetic cell strategy can be expanded to a number of different magnetic biomaterials for various tissue engineering applications.