Silicium Dioxide Nanoparticles As Carriers for Photoactivatable CO-Releasing Molecules (PhotoCORMs)

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• 作者：Gregor Do虉rdelmann ; Hendrik Pfeiffer ; Alexander Birkner ; Ulrich Schatzschneider
• 刊名：Inorganic Chemistry
• 出版年：2011
• 出版时间：May 16, 2011
• 年：2011
• 卷：50
• 期：10
• 页码：4362-4367
• 全文大小：874K
• 年卷期：v.50,no.10(May 16, 2011)
• ISSN：1520-510X

文摘

Silicium dioxide nanoparticles of about 20 nm diameter containing azido groups at the surface were prepared by emulsion copolymerization of trimethoxymethylsilane and (3-azidopropyl)triethoxysilane and studied by transmission electron microscopy (TEM). A photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)₃(tpm)]⁺ (tpm = tris(pyrazolyl)methane) containing an alkyne-functionalized tpm ligand was covalently linked to the silicium dioxide nanoparticles via the copper-catalyzed azide鈥揳lkyne 1,3-dipolar cycloaddition (CuAAC 鈥渃lick鈥?reaction). The surface functionalization of the particles with azido groups and manganese CORMs was analyzed by UV鈥搗is, IR, ¹H and ¹³C CP-MAS NMR spectroscopies as well as energy-dispersive X-ray spectroscopy (EDX). The myoglobin assay was used to demonstrate that the CORM-functionalized nanoparticles have photoinducible CO-release properties very similar to the free complex. In the future, such functionalized silicium dioxide nanoparticles might be utilized as delivery agents for CORMs in solid tumors.