An Atom-Economical Access to 尾-Heteroarylated Ketones from Propargylic Alcohols via Tandem Ruthenium/Indium Catalysis

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• 作者：Barry M. Trost ; Alexander Breder
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：February 4, 2011
• 年：2011
• 卷：13
• 期：3
• 页码：398-401
• 全文大小：186K
• 年卷期：v.13,no.3(February 4, 2011)
• ISSN：1523-7052

文摘

The direct and chemoselective synthesis of 尾-heteroarylated ketones from secondary propargyl alcohols through tandem Ru/In catalysis is reported. Both electron-rich and neutral heteroarenes, such as furans and indoles, efficiently undergo the redox isomerization/conjugate addition (RICA) sequence to provide the corresponding adducts in yields of up to 97%.