Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure
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- 作者：Alexey V. Tkach ; Galina V. Shurin ; Michael R. Shurin ; Elena R. Kisin ; Ashley R. Murray ; Shih-Houng Young ; Alexander Star ; Bengt Fadeel ; Valerian E. Kagan ; Anna A. Shvedova
- 刊名：ACS Nano
- 出版年：2011
- 出版时间：July 26, 2011
- 年：2011
- 卷：5
- 期：7
- 页码：5755-5762
- 全文大小：945K
- 年卷期：0
- ISSN：1936-086X
文摘
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.