Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles
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- 作者：Stephan A. Mackowiak ; Alexandra Schmidt ; Veronika Weiss ; Christian Argyo ; Constantin von Schirnding ; Thomas Bein ; Christoph Br盲uchle
- 刊名：Nano Letters
- 出版年：2013
- 出版时间：June 12, 2013
- 年：2013
- 卷：13
- 期：6
- 页码：2576-2583
- 全文大小：547K
- 年卷期：v.13,no.6(June 12, 2013)
- ISSN：1530-6992
文摘
Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.